Reaktion #1269869

Reaktionsgleichung

Et3N

tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

benzoyl chloride

→

tert-butyl 7-benzoyl-2,7-diazaspiro[4.4]nonane-2-carboxylate

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction was quenched with water (10 mL)
2. 2
   ExtraktionThe aqueous layer was extracted with EtOAc (3×10 mL)
3. 3
   TrocknenThe combined organic phase was dried over MgSO4
4. 4
   Einengenconcentrated
5. 5
   Sonstigeto give a residue which
6. 6
   Sonstigewas purified by silica gel chromatography

Vorschrift

Et3N (0.5 mL) was added into a solution of tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (0.2 g) and benzoyl chloride (0.1 mL) in THF (10 mL). The mixture was heated to 115° C. for 24 hours. The reaction was quenched with water (10 mL). The aqueous layer was extracted with EtOAc (3×10 mL). The combined organic phase was dried over MgSO4 and concentrated to give a residue which was purified by silica gel chromatography to give tert-butyl 7-benzoyl-2,7-diazaspiro[4.4]nonane-2-carboxylate.

Quelle