Reaktion #1269867

Reaktionsgleichung

Et3N

tert-butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate

5-chloro-1-phenyl-1H-tetrazole

→

tert-butyl 7-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane-2-carboxylate

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction was quenched with water (50 mL)
2. 2
   ExtraktionThe aqueous layer was extracted with EtOAc (3×50 mL)
3. 3
   TrocknenThe combined organic phase was dried over MgSO4
4. 4
   Einengenconcentrated
5. 5
   Sonstigeto give a residue which
6. 6
   Sonstigewas purified by silica gel chromatography

Vorschrift

Et3N (5 mL) was added into a solution of tert-butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate (1 g) and 5-chloro-1-phenyl-1H-tetrazole (1 g) in dioxane (50 mL). The mixture was heated to 115° C. for 24 hours. The reaction was quenched with water (50 mL). The aqueous layer was extracted with EtOAc (3×50 mL). The combined organic phase was dried over MgSO4 and concentrated to give a residue which was purified by silica gel chromatography to give tert-butyl 7-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane-2-carboxylate.

Quelle