Reaktion #1269863

Reaktionsgleichung

4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester

HCl

→

4-(2-Amino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester hydrochloride

Lösungsmittel

Et2O

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe white cake was filtered
2. 2
   Waschenwashed with Et2O
3. 3
   Sonstigedried at HV overnight
4. 4
   SonstigeThe crude (1.19 g) was used without purification

Vorschrift

To a solution of 4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester (1.79 g, as described in WO2008044217) in CH2Cl2 (22 mL) was added HCl (4M in dioxane, 8.3 mL) and the reaction mixture was stirred for 2 h at RT. The suspension was diluted with Et2O (1000 mL) and the white cake was filtered, washed with Et2O and dried at HV overnight. The crude (1.19 g) was used without purification.

Quelle