Reaktion #1269836

Reaktionsgleichung

3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole

water

formamide

→

4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is cooled to 30° C.
2. 2
   SonstigeThe solid is collected
3. 3
   Waschenwashed well with water
4. 4
   Trocknenwith methanol and dried in air

Vorschrift

3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole (29.5 g) is suspended in formamide (300 mL) and heated under nitrogen at 180° C. for 4 hours. The reaction mixture is cooled to 30° C. and water (300 mL) is added. The solid is collected, washed well with water, then with methanol and dried in air to give of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine.

Quelle