Reaktion #1268397

Reaktionsgleichung

2-amino-4-chloro-6-neopentylpyrimidine

sodium acetate

acetic acid

4-chlorobenzene-diazonium hexafluorophosphate

acetic acid

→

4-chloro-2,5-diamino-6-neopentyl-pyrimidine

Lösungsmittel

water

EtOH-H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionExtraction and evaporation
2. 2
   Sonstigegave a yellow solid which
3. 3
   ExtraktionExtraction and chromatography

Vorschrift

A mixture of 2-amino-4-chloro-6-neopentylpyrimidine (1 mmol), sodium acetate (14 mmol), acetic acid (86 mmol), and 4-chlorobenzene-diazonium hexafluorophosphate (1.15 mmol) in water was stirred at 25° C. for 12 h. Extraction and evaporation gave a yellow solid which was treated with zinc dust (10 mmol) and acetic acid (5.54 mmol) in EtOH-H2O at 80° C. for 1 h. Extraction and chromatography gave 4-chloro-2,5-diamino-6-neopentyl-pyrimidine as a yellow solid. TLC: Rf=0.25, 50% EtOAc-hexane.

Quelle