Reaktion #1268

ord-b5c1249063ad41ecb9a886e640b8e144

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCN(c2ccc3oc(C(N)=O)cc3c2)CC1
5-(4-tert-butoxycarbonyl-1-piperazinyl)-benzofuran-2-carboxamide
→
NC(=O)c1cc2cc(N3CCNCC3)ccc2o1
5-(1-piperazinyl)benzofuran-2-carboxamide

Edukte

CC(C)(C)OC(=O)N1CCN(c2ccc3oc(C(N)=O)cc3c2)CC1
5-(4-tert-butoxycarbonyl-1-piperazinyl)-benzofuran-2-carboxamide

Reagenzien

Keine

Lösungsmittel

Cl
HCl

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

1 g of 5-(4-tert-butoxycarbonyl-1-piperazinyl)-benzofuran-2-carboxamide is dissolved in 50 ml of methanolic HCl and stirred for I hour. After customary working up, 5-(1-piperazinyl)benzofuran-2-carboxamide, m.p. 252°-255°, is obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05723614uspto-grants-1998_03