Reaktion #1266879

Reaktionsgleichung

water

5-hydroxy-2-methoxypyridine

2,3,5-trichloropyridine

potassium hydroxide

→

title compound

Ausbeute 88.2%

5-(3,5-Dichloro-pyridin-2-yloxy)-2-methoxy-pyridine

Ausbeute 88.2%

Lösungsmittel

dimethyl sulfoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe precipitate was collected by suction
2. 2
   Waschenwashed thoroughly with water
3. 3
   Sonstigedried in a vacuum oven at 45° C.

Vorschrift

A solution of 5-hydroxy-2-methoxypyridine (1.25 g, 10.0 mmol), 2,3,5-trichloropyridine (1.82 g, 10.0 mmol) and potassium hydroxide (85% pure, 1.08 g, 10.0 mmol) in dimethyl sulfoxide (25 mL) was heated at 90° C. for 1.5 hours. The solution was poured slowly into water (200 mL). The precipitate was collected by suction, washed thoroughly with water and dried in a vacuum oven at 45° C., yielding the title compound (2.39 g, 88% yield).

Quelle