Reaktion #1266877

Reaktionsgleichung

water

5-hydroxy-2-methoxypyridine

2-chloro-5-trifluoromethylpyridine

potassium hydroxide

→

title compound

Ausbeute 95.0%

2-Methoxy-5-(5-trifluoromethyl-pyridin-2-yloxy)-pyridine

Ausbeute 95.0%

Lösungsmittel

dimethyl sulfoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling with an external ice-bath
2. 2
   Sonstigethe precipitate was collected by suction
3. 3
   Waschenwashed thoroughly with water
4. 4
   Sonstigedried in a vacuum oven at 45° C.

Vorschrift

A solution of 5-hydroxy-2-methoxypyridine (1.25 g, 10.0 mmol), 2-chloro-5-trifluoromethylpyridine (1.82 g, 10.0 mmol) and potassium hydroxide (85% pure, 1.08 g, 10.0 mmol) in dimethyl sulfoxide (25 mL) was heated at 90° C. for 2.5 hours. The solution was cooled to room temperature and poured slowly into water (200 mL). After cooling with an external ice-bath, the precipitate was collected by suction, washed thoroughly with water and dried in a vacuum oven at 45° C., yielding the title compound (2.56 g, 95% yield).

Quelle