Reaktion #1262352

ord-28c635fa97fb405ca8c2bc8875851d50

Reaktionsgleichung

Oc1cc(F)cc(Br)c1
3-Bromo-5-fluoro-phenol
BrCCOCCBr
2-bromoethylether
O=C([O-])[O-].[K+].[K+]
K2CO3
O=C([O-])O.[Na+]
NaHCO3
→
COCCOc1cc(F)cc(Br)c1
title compound
COCCOc1cc(F)cc(Br)c1
1-Bromo-3-fluoro-5-(2-methoxy-ethoxy)-benzene

Edukte

Oc1cc(F)cc(Br)c1
3-Bromo-5-fluoro-phenol
BrCCOCCBr
2-bromoethylether
O=C([O-])[O-].[K+].[K+]
K2CO3
O=C([O-])O.[Na+]
NaHCO3

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF
CCOC(C)=O
ethyl acetate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

3-Bromo-5-fluoro-phenol (5.0 g, 26.2 mmol), 2-bromoethylether (4.0 g, 28.8 mmol) and K2CO3 (4.4 g, 31.4 mmol) are mixed in 50 ml DMF and stirred at 50 C overnight. Addition of aqueous NaHCO3 solution and extraction into ethyl acetate yields the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07838674B2uspto-grants-2010_11