Reaktion #1260581

ord-4c730d773c1b4d83a55ab081b5799189

Reaktionsgleichung

N#Cc1ccc(N(CCCO)CC(F)(F)F)cc1C(F)(F)F
4-[(3-hydroxypropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile
CC(=O)Nc1ccc(O)cc1
4-acetamidophenol
→
CC(=O)Nc1ccc(OCCCN(CC(F)(F)F)c2ccc(C#N)c(C(F)(F)F)c2)cc1
N-[4-({3-[[4-Cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]propyl}oxy)phenyl]acetamide

Edukte

N#Cc1ccc(N(CCCO)CC(F)(F)F)cc1C(F)(F)F
4-[(3-hydroxypropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile
CC(=O)Nc1ccc(O)cc1
4-acetamidophenol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeSynthesized

Vorschrift

Synthesized as described in Example 1C from 4-[(3-hydroxypropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 4-acetamidophenol: MS (APCI) m/z 460 (M+1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07834063B2uspto-grants-2010_11