Reaktion #1260580

ord-df99e4762e194b1a9d2b1c7e0ec97d28

Reaktionsgleichung

N#Cc1ccc(NCC(F)(F)F)cc1C(F)(F)F
4-(2,2,2-trifluoro-ethylamino)-2-trifluoromethyl-benzonitrile
CC(C)(C)[Si](C)(C)OCCCBr
[(3-bromopropyl)oxy](1,1-dimethylethyl)dimethylsilane
→
N#Cc1ccc(N(CCCO)CC(F)(F)F)cc1C(F)(F)F
4-[(3-Hydroxypropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Edukte

N#Cc1ccc(NCC(F)(F)F)cc1C(F)(F)F
4-(2,2,2-trifluoro-ethylamino)-2-trifluoromethyl-benzonitrile
CC(C)(C)[Si](C)(C)OCCCBr
[(3-bromopropyl)oxy](1,1-dimethylethyl)dimethylsilane

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeSynthesized

Vorschrift

Synthesized as described in Example 1B from 4-(2,2,2-trifluoro-ethylamino)-2-trifluoromethyl-benzonitrile and [(3-bromopropyl)oxy](1,1-dimethylethyl)dimethylsilane: MS (APCI) m/z 327 (M+1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07834063B2uspto-grants-2010_11