Reaktion #1257667

Reaktionsgleichung

N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-chloro-acetamide

methylamine

→

N-(2-benzo[1,3]dioxol-5-yl-ethyl)-2-methylamino-acetamide

Ausbeute 68.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter this time, the solution was concentrated down under N2 gas
2. 2
   SonstigeThe crude material was purified by prep-LCMS

Vorschrift

N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-chloro-acetamide (32 mg, 0.13 mmol) was dissolved in methylamine in anhydrous ethanol (33% by wt., 5 mL). The solution was allowed to stir at room temperature for 16 hours. After this time, the solution was concentrated down under N2 gas. The crude material was purified by prep-LCMS to afford 21 mg (68%) of N-(2-benzo[1,3]dioxol-5-yl-ethyl)-2-methylamino-acetamide. 1H-NMR (400 MHz, CD3OD) δ 6.73-6.65 (m, 3H), 5.89 (s, 2H), 3.46-3.39 (t, 2H), 3.31-3.29 (m, 2H), 2.74-2.70 (t, 2H), 2.35 (s, 3H).

Quelle