Reaktion #1257390

ord-1d1b8573617440829c8966ece8ceda23

Reaktionsgleichung

O=[N+]([O-])c1cccc2nc(Cl)ccc12
5-nitro-2-chloroquinoline
CC1(C)Cc2cccc(N)c2O1
7-amino-2,3-dihydro-2,2-dimethylbenzofuran
CC(=O)c1nccs1
2-acetylthiazole
→
CC(Nc1cccc2nc(Nc3cccc4c3OC(C)(C)C4)ccc12)c1nccs1
title compound
CC(Nc1cccc2nc(Nc3cccc4c3OC(C)(C)C4)ccc12)c1nccs1
rac-N2-(2,2-Dimethyl-2,3-dihydro-benzofuran-7-yl)-N5-(1-thiazol-2-yl-ethyl)-quinoline-2,5-diamine

Edukte

O=[N+]([O-])c1cccc2nc(Cl)ccc12
5-nitro-2-chloroquinoline
CC1(C)Cc2cccc(N)c2O1
7-amino-2,3-dihydro-2,2-dimethylbenzofuran
CC(=O)c1nccs1
2-acetylthiazole

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound, MS: m/e=417.4 (M+H+), was prepared from 5-nitro-2-chloroquinoline, 7-amino-2,3-dihydro-2,2-dimethylbenzofuran (CAS 68298-46-4) and 2-acetylthiazole as described in example 26.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07825253B2uspto-grants-2010_11