Reaktion #1257129

ord-7979f9b6a826464c92354f9062a90e40

Reaktionsgleichung

O=S(=O)(c1ccc(CO)cc1)N1CCCC1
4-(pyrrolidine-1-sulfonyl)-benzyl alcohol
O=C(O)Cc1cc(OCc2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)c1
(5-benzyloxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid
O=C(O)Cc1cc(OCc2ccc(S(=O)(=O)N3CCCC3)cc2)cc(-c2ccc(C(F)(F)F)cc2)c1
5-[4-(pyrrolidine-1-sulfonyl)-benzyloxy]-4′-trifluoromethyl-biphenyl-3-yl-acetic acid
OCc1ccccc1
benzyl alcohol
→
CCCC(C(=O)O)c1cc(OCc2ccc(S(=O)(=O)N3CCCC3)cc2)cc(-c2ccc(C(F)(F)F)cc2)c1
2-{5-[4-(pyrrolidine-1-sulfonyl)-benzyloxy]-4′-trifluoromethyl-biphenyl-3-yl}-pentanoic acid

Edukte

O=S(=O)(c1ccc(CO)cc1)N1CCCC1
4-(pyrrolidine-1-sulfonyl)-benzyl alcohol
O=C(O)Cc1cc(OCc2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)c1
(5-benzyloxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid
O=C(O)Cc1cc(OCc2ccc(S(=O)(=O)N3CCCC3)cc2)cc(-c2ccc(C(F)(F)F)cc2)c1
5-[4-(pyrrolidine-1-sulfonyl)-benzyloxy]-4′-trifluoromethyl-biphenyl-3-yl-acetic acid
OCc1ccccc1
benzyl alcohol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Procedure as for example 110 replacing (5-benzyloxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid with 5-[4-(pyrrolidine-1-sulfonyl)-benzyloxy]-4′-trifluoromethyl-biphenyl-3-yl-acetic acid, itself made according to the procedure of example 9 replacing benzyl alcohol with 4-(pyrrolidine-1-sulfonyl)-benzyl alcohol, afforded 2-{5-[4-(pyrrolidine-1-sulfonyl)-benzyloxy]-4′-trifluoromethyl-biphenyl-3-yl}-pentanoic acid, LC method B, retention time 12.6 min.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07825160B2uspto-grants-2010_11