Reaktion #1256734

Reaktionsgleichung

[1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]acetonitrile

di-terbutyl carbonate

Sodium borohydride

→

tert-butyl {2-[1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]ethyl}carbamate

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONis added portionwise to the reaction mixture
2. 2
   Sonstigeis allowed to room temperature

Vorschrift

The [1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]acetonitrile (4.76 mmol, 0.90 g), the di-terbutyl carbonate (9.52 mmol, 2.08 g) and nickel chloride hexahydrate (4.77 mmol, 1.13 g) are added to methanol (10 ml) at room temperature. Sodium borohydride (13.1 mmol, 0.49 g). is added portionwise to the reaction mixture. The reaction mixture is allowed to room temperature and stirred for three hours.

Quelle