Reaktion #1255970

Reaktionsgleichung

7-Methoxy-3-nitroquinolin-4-ol

ammonium hydroxide

hydrochloric acid

→

3-amino-7-methoxyquinolin-4-ol hydrochloride

Lösungsmittel

methanol

diethyl ether

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered
2. 2
   EinengenThe filtrate was concentrated under vacuum
3. 3
   Sonstigeto provide a green solid
4. 4
   SonstigeThe resulting precipitate was isolated by filtration
5. 5
   Sonstigedried

Vorschrift

7-Methoxy-3-nitroquinolin-4-ol (4.5 g, 20.4 mmol), methanol (250 mL), ammonium hydroxide (5 mL) and palladium on carbon (400 mg of 10%) were combined. The mixture was placed on a Parr apparatus under a hydrogen atmosphere at 40 psi (2.8 Kg/cm2) for 2 hrs. The reaction mixture was filtered. The filtrate was concentrated under vacuum to provide a green solid. This material was dissolved in methanol (20 mL) and then 1N hydrochloric acid in diethyl ether (75 mL) was added. The resulting precipitate was isolated by filtration and dried to provide 2.6 g of 3-amino-7-methoxyquinolin-4-ol hydrochloride as a pink solid.

Quelle