Reaktion #1254808

Reaktionsgleichung

6-phenyl-2-(4-trifluoromethylphenyl)-4-(3H)-pyrimidinone

phosphorus oxychloride

sodium hydroxide

→

desired compound

Ausbeute 89.8%

4-chloro-6-phenyl-2-(4-trifluoromethylphenyl)pyrimidine

Ausbeute 89.8%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitates are collected by filtration
2. 2
   Waschenwashed with water
3. 3
   Sonstigerecrystallized from isopropyl alcohol

Vorschrift

A mixture of 6-phenyl-2-(4-trifluoromethylphenyl)-4-(3H)-pyrimidinone (10 g) and phosphorus oxychloride (7.3 g) was stirred at 80° C. for 3 hours. To the reaction mixture is added water, and the mixture is neutralized with an aqueous sodium hydroxide solution (1 mol/L). The precipitates are collected by filtration, washed with water, and recrystallized from isopropyl alcohol to give the desired compound (9.5 g).

Quelle