Reaktion #1254650

Reaktionsgleichung

intermediate

3-(4-(3-Hydroxy-1-azetidinyl)-3-fluorophenyl)-5(R)-(isoxazol-3-yl-oxymethyl)oxazolidin-2-one

3-(3-fluoro-4-(2-methyl-imidazol-1-yl)phenyl)-5(R)-hydroxymethyloxazolidin-2-one

→

title compound

3-(3-Fluoro-4-(2-methyl-imidazol-1-yl)phenyl)-5(R)-(isoxazol-3-yl-oxymethyl)oxazolidin-2-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigepurifying by chromatography on a 10 g silica Mega Bond Elut® column
2. 2
   Wascheneluting with a gradient
3. 3
   Temperaturincreasing in polarity from 0 to 2.5% MeOH in dichloromethane

Vorschrift

Using essentially the same procedure as for the intermediate of Example 65, but starting with 3-(3-fluoro-4-(2-methyl-imidazol-1-yl)phenyl)-5(R)-hydroxymethyloxazolidin-2-one (202 mg, 0.69 mmol), and purifying by chromatography on a 10 g silica Mega Bond Elut® column, eluting with a gradient increasing in polarity from 0 to 2.5% MeOH in dichloromethane, the title compound was prepared (137 mg).

Quelle