Reaktion #1254

ord-4c3ca7fee7ca4cb68a75ae1c5be3919e

Reaktionsgleichung

Cc1ccc(C(=O)O)cc1
4-methylbenzoic acid
O=S(Cl)Cl
thionyl chloride
→
Cc1ccc(C(=O)Cl)cc1
4-Methylbenzoyl chloride

Edukte

Cc1ccc(C(=O)O)cc1
4-methylbenzoic acid
O=S(Cl)Cl
thionyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.DISTILLATIONafter excess thionyl chloride was distilled off

Vorschrift

4-Methylbenzoyl chloride was prepared in a conventional manner from 4-methylbenzoic acid and thionyl chloride and after excess thionyl chloride was distilled off, was used as the crude product in the side chain chlorination.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05723613uspto-grants-1998_03