Reaktion #1253193

Reaktionsgleichung

lauryl alcohol

triethyl amine

p-toluene sulphonyl chloride

→

lauryl tosylate

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe reaction mixture was then washed with 20% sodium chloride solution (500 ml)
2. 2
   TrocknenThe washed organic layer was dried over anhydrous sodium sulphate
3. 3
   SonstigeRemoval of solvent under vacuo
4. 4
   Sonstigeresulted in colorless oil that

Vorschrift

To a stirred and a cooled solution of lauryl alcohol (186.0 g, 1.0 mole) and triethyl amine (121.0 g, 1.2 mole) in dichloromethane (600 ml), p-toluene sulphonyl chloride (228.0 g, 1.2 mole) in dichloromethane (400 ml) was slowly added and the reaction was continued at room temperature for 10 hours. The reaction mixture was then washed with 20% sodium chloride solution (500 ml). The washed organic layer was dried over anhydrous sodium sulphate. Removal of solvent under vacuo resulted in colorless oil that solidified on keeping to yield lauryl tosylate. (309.0 g, 91%), m. p. 29° C. (literature m. p. 29° C.).

Quelle