Reaktion #1249314

Reaktionsgleichung

HCl

product

2-(3-Bromoimidazo[1,2-b]pyridazin-6-ylamino)ethanol

(E)-1-hexeneboronic acid

HCl

→

title compound

Ausbeute 53.0%

(E)-2-(3-(Hex-1-enyl)imidazo[1,2-b]pyridazin-6-ylamino)ethanol hydrochloride

Ausbeute 53.0%

Lösungsmittel

Et2O

Reaktionsbedingungen

Vorschrift

Prepared from the product of step A and (E)-1-hexeneboronic acid according to general procedure 2. The free-base was converted to the HCl salt with 2N HCl in Et2O to provide the title compound (45 mg, 53%) as a white solid; 1H NMR (500 MHz, CD3OD) δ 7.91 (s, 1H), 7.88 (d, J=9.8 Hz, 1H), 7.22 (d, J=9.8 Hz, 1H), 6.88 (dt, J=7.0, 16.2 Hz, 1H), 6.67 (d, J=16.2 Hz, 1H), 3.81 (t, J=5.7 Hz, 2H), 3.55 (t, J=5.7 Hz, 2H), 2.36-2.32 (m, 2H), 1.55-1.49 (m, 2H), 1.46-1.40 (m, 2H), 0.96 (t, J=7.3 Hz, 3H); 13C NMR (125 MHz, CD3OD) δ 157.3, 139.2, 133.2, 130.2, 121.0, 120.8, 117.6, 114.2, 60.5, 45.0, 34.3, 32.3, 23.3, 14.3; HPLC tR=10.8 min (Luna), 98.8%; ES-MS: (M+H)=261 m/z.

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