Reaktion #1249313

Reaktionsgleichung

CH2Cl2 MeOH NH4OH

3-bromo-6-chloroimidazo[1,2-b]pyridazine

2-aminoethanol

→

2-(3-Bromoimidazo[1,2-b]pyridazin-6-ylamino)ethanol

Reaktionsbedingungen

Vorschrift

Prepared from 3-bromo-6-chloroimidazo[1,2-b]pyridazine and 2-aminoethanol according to general procedure 1 providing the intermediate (78 mg, 32%) as a white solid: Rf=0.41 (CH2Cl2/MeOH/NH4OH, 160:18:2); 1H NMR (500 MHz, CD3OD) δ 7.55 (d, J=9.7 Hz, 1H), 7.40 (s, 1H), 6.73 (d, J=9.7 Hz, 1H), 3.80 (t, J=5.7 Hz, 2H), 3.52 (t, J=5.7 Hz, 2H); ES-MS: (M+H)=257, 259 m/z.

Quelle