Reaktion #1248537

Reaktionsgleichung

7-Bromo-bicyclo[2.2.1]heptane

magnesium

DMF

→

white solid

Ausbeute 48.4%

Bicyclo[2.2.1]heptane-7-carbaldehyde

Ausbeute 48.4%

Lösungsmittel

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 2.5 h
2. 2
   TemperaturThe mixture was then refluxed for 2 h
3. 3
   Temperaturcooled to room temperature
4. 4
   Filtrationthe white solid filtered off
5. 5
   Waschenwashed with ether

Vorschrift

15.9 g (81 mmol) of 7-Bromo-bicyclo[2.2.1]heptane were added dropwise to 2 g magnesium (81 mmol) in 25 ml of diethyl ether and refluxed for 2.5 h. The mixture was cooled to 0-5° C. and 6.3 ml (81 mmol) of DMF were added dropwise. The mixture was then refluxed for 2 h, cooled to room temperature and the white solid filtered off and washed with ether. The filtrate was reduced and 4.87 g of a white solid were obtained. The intermediate was used without further characterization.

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