Reaktion #1248219

Reaktionsgleichung

acetyl chloride

2-methyl-3-nitrophenol

AlCl3

→

title compound

Ausbeute 47.3%

1-(2-Hydroxy-3-methyl-4-nitro-phenyl)-ethanone

Ausbeute 47.3%

Lösungsmittel

nitrobenzene

nitrobenzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction is heated to 120° C
2. 2
   Temperaturthe reaction mixture is cooled to RT
3. 3
   Sonstigequenched slowly into a 1N HCl/ice mixture
4. 4
   Extraktionextracted with EtOAc (3×)
5. 5
   Einengenconcentrated
6. 6
   SonstigeThe resulting residue is purified by flash column chromatography
7. 7
   SonstigeObtained

Vorschrift

To a solution of 2-methyl-3-nitrophenol (2.0 g, 13 mmol) in nitrobenzene (16 mL) at RT under Ar gas is added AlCl3 (3.9 g, 29 mmol). The reddish mixture is heated to 50° C. To the reddish mixture is added dropwise via addition funnel a solution of acetyl chloride (1.2 mL, 17 mmol) in nitrobenzene (10 mL). The reaction is heated to 120° C. After 2 h at 120° C., the reaction mixture is cooled to RT and quenched slowly into a 1N HCl/ice mixture. The resulting mixture is stirred for 30 min and extracted with EtOAc (3×). The organic layers are combined and concentrated. Water is used to azeotrope off the nitrobenzene. The resulting residue is purified by flash column chromatography using 20% EtOAc/hexane. Obtained is the title compound as reddish oil (1.2 g). The title compound is 60% pure by LC-MS. Compound is used as is in the next step. LC-MS (m/e): 194 (M−1).

Quelle