Reaktion #1246015

ord-6898a7aadb194b78a2017f1756275031

Reaktionsgleichung

CN(C(=O)OC(C)(C)C)c1ccc2c(Sc3ccccc3C#N)cn(Cc3ccccn3)c2c1
[3-(2-cyano-phenylsulfanyl)-1-pyridin-2-ylmethyl-1H-indol-6-yl]-methyl-carbamic acid tert-butyl ester
CNc1ccc2c(Sc3ccccc3C#N)cn(Cc3ccccn3)c2c1
2-(6-Methylamino-1-pyridin-2-ylmethyl-1H-indol-3-ylsulfanyl)-benzonitrile

Lösungsmittel

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigethe product obtained in the previous step (0.150 g, 0.33 mmol)
  2. 2
    Sonstigeto give

Vorschrift

v)—Following a procedure analogous to that described under step i of Example 2, the product obtained in the previous step (0.150 g, 0.33 mmol) was methylated to give, after column chromatography (toluene/acetone 8:2), [3-(2-cyano-phenylsulfanyl)-1-pyridin-2-ylmethyl-1H-indol-6-yl]-methyl-carbamic acid tert-butyl ester (0.044 g).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07812036B2uspto-grants-2010_10