Reaktion #1245796

Reaktionsgleichung

Morpholine

2,4,6-trichloropyridine

sodium carbonate

→

title compound

Ausbeute 30.5%

4-(4,6-Dichloropyridin-2-yl)-morpholine

Ausbeute 30.5%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to ambient temperature
2. 2
   Filtrationfiltered through celite and
3. 3
   Einengenconcentrated in vacuo

Vorschrift

Morpholine (5.0 g) was added to a suspension of 2,4,6-trichloropyridine (10.0 g) and sodium carbonate (5.9 g) in acetonitrile (100 mL). The reaction mixture was then stirred at 70° C. for 16 hours, cooled to ambient temperature, filtered through celite and concentrated in vacuo. The crude product was subjected to flash chromatography (SiO2, heptane/ethylacetate 4:1) to furnish 3.90 g (30% yield) of the title compound as an off-white solid. LC-MS (m/z) 323.8 (M+); tR=3.10, (UV, ELSD) 98.5%, 98.9%. 1H NMR (500 MHz, CDCl3): 3.50 (m, 4H), 3.80 (m, 4H), 6.45 (s, 1H), 6.67 (s, 1H).

Quelle