Reaktion #1244

Reaktionsgleichung

( 16 )

3-(4-fluorophenyl)-2,1-benzisoxazole

→

2-amino-4'-fluorobenzophenone

Lösungsmittel

tetrahydrofuran

triethylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe vigorously stirred suspension is flushed with hydrogen gas
2. 2
   Sonstige8-10 hours
3. 3
   SonstigeThe catalyst is removed by filtration through a bed of celite
4. 4
   Sonstigethe solvent is removed under reduced pressure
5. 5
   SonstigeThe product (16) is recrystallized from toluene

Vorschrift

To a suspension of (16) (42.6 g, 0.2 mol) in 750 ml of dry tetrahydrofuran (THF) and 20 ml of triethylamine is added 5% palladium on charcoal (6 g). The vigorously stirred suspension is flushed with hydrogen gas and stirred at room temperature under a hydrogen atmosphere until absorption of hydrogen ceases (approximately 90-90% of the molar amount; 8-10 hours). The catalyst is removed by filtration through a bed of celite, and the solvent is removed under reduced pressure. The product (16) is recrystallized from toluene.

Quelle