Reaktion #1243289

Reaktionsgleichung

2,3,4,5,6-pentafluorobenzoic acid

ammonia

→

4-amino-2,3,5,6-tetrafluorobenzoic acid

Lösungsmittel

nitromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated at 100° for 20 hrs
2. 2
   SonstigeThe resulting solution is evaporated
3. 3
   Sonstigethe residue crystallized from chloroform-hexane

Vorschrift

A mixture of 10.0 g of 2,3,4,5,6-pentafluorobenzoic acid and 400 ml of nitromethane is saturated with anhydrous ammonia at room temperature and then placed in a bomb and heated at 100° for 20 hrs. The resulting solution is evaporated and the residue crystallized from chloroform-hexane to yield 4-amino-2,3,5,6-tetrafluorobenzoic acid as a white solid.

Quelle