Reaktion #1224

Reaktionsgleichung

4-iodo-2-trichloroacetylpyrrole

methanol

sodium methoxide

→

methyl 4-iodo-2-pyrrolecarboxylate

Lösungsmittel

water

ethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction medium evaporated to dryness
2. 2
   Sonstigethe residue obtained
3. 3
   SonstigeThe organic phase was decanted off
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Sonstigeevaporated
6. 6
   SonstigeThe residue obtained
7. 7
   Sonstigewas triturated in heptane
8. 8
   Filtrationfiltered
9. 9
   Sonstige4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered

Vorschrift

8.2 g (24 mmol) of 4-iodo-2-trichloroacetylpyrrole and 100 ml of methanol were introduced into a round-bottomed flask and 2 g (36 mmol) of sodium methoxide were added. The mixture was stirred at room temperature for four hours, the reaction medium evaporated to dryness, and the residue obtained taken up in water and ethyl ether. The organic phase was decanted off, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane and filtered; 4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered.

Quelle