Reaktion #1206

Reaktionsgleichung

ethanolamine

1-tetradecyloxy-3-methyl-2-butene oxide

→

title compound

Ausbeute 58.0%

3-(2-hydroxyethylamino)-4-tetradecyloxy-2-methyl-2-butanol

Ausbeute 58.0%

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA 100-ml two-necked flask equipped with a stirrer and a dropping funnel
2. 2
   TemperaturWhile heating
3. 3
   TemperaturAfter heating
4. 4
   workup.STIRRINGstirring the mixture further for 16 hours
5. 5
   Sonstigethe resultant reaction mixture
6. 6
   Einengenwas concentrated under reduced pressure
7. 7
   Sonstigethe resultant residue was purified by column chromatography on silica gel

Vorschrift

A 100-ml two-necked flask equipped with a stirrer and a dropping funnel was charged with 15.3 g (16.7 mmol) of ethanolamine and 5.0 g of ethanol. While heating and stirring the mixture at 80° C. in a nitrogen atmosphere, an ethanol solution of 5.00 g (16.7 mmol) of 1-tetradecyloxy-3-methyl-2-butene oxide was added dropwise over 3 hours. After heating and stirring the mixture further for 16 hours, the resultant reaction mixture was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 3.47 g (yield: 58%) of the title compound (IIc-4).

Quelle