Reaktion #12008

ord-e07af560f18e4cd3afc3bb14e37b2cbe

Reaktionsgleichung

C[C@@H]1CNC(=O)c2cc3ccc(Cl)nc3n21
intermediate b
C[C@@H]1CNC(=O)c2cc3ccc(Cl)nc3n21
(R)-6-chloro-4-methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one
CCOC(=O)c1cc2ccc(Br)nc2n1[C@H](C)CNC(=O)OC(C)(C)C
(R)-6-bromo-1-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester
→
C[C@@H]1CNC(=O)c2cc3ccc(Br)nc3n21
(R)-6-Bromo-4-methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

Edukte

C[C@@H]1CNC(=O)c2cc3ccc(Cl)nc3n21
intermediate b
C[C@@H]1CNC(=O)c2cc3ccc(Cl)nc3n21
(R)-6-chloro-4-methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one
CCOC(=O)c1cc2ccc(Br)nc2n1[C@H](C)CNC(=O)OC(C)(C)C
(R)-6-bromo-1-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

This compound was prepared in analogy to Example 1, intermediate b) from (R)-6-bromo-1-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07098337B2uspto-grants-2006_08