Reaktion #12007

ord-2a9a89ab74244856b7ae661c9abb9021

Reaktionsgleichung

CCOC(=O)c1cc2ccc(Br)nc2[nH]1
6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester
CC(C)(C)[O-].[K+]
potassium tert-butoxide
C[C@H]1CN(C(=O)OC(C)(C)C)S(=O)(=O)O1
(S)-5-methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester
→
CCOC(=O)c1cc2ccc(Br)nc2n1[C@H](C)CNC(=O)OC(C)(C)C
(R)-6-Bromo-1-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester

Edukte

CCOC(=O)c1cc2ccc(Br)nc2[nH]1
6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester
CC(C)(C)[O-].[K+]
potassium tert-butoxide
C[C@H]1CN(C(=O)OC(C)(C)C)S(=O)(=O)O1
(S)-5-methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

This compound was prepared in analogy to Example 1, intermediate a) from 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester, potassium tert-butoxide and (S)-5-methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07098337B2uspto-grants-2006_08