Reaktion #1199542

ord-df8f6814805e4c65b992f3fa7631aad6

Reaktionsgleichung

CC[C@]12CCCN3CCc4c(n(c5ccccc45)[C@@](O)(C(=O)OC)C1)[C@@H]32
vincamine
O=C(O)c1cc(O)ccc1O
2,5dihydroxybenzoic acid
CC[C@]12CCCN3CCc4c(n(c5ccccc45)[C@@](O)(C(=O)OC)C1)[C@@H]32
vincamine
→
CC[C@]12CCCN3CCc4c(n(c5ccccc45)[C@@](O)(C(=O)OC)C1)[C@@H]32.O=C([O-])c1cc(O)ccc1O
Vincamine 2,5-dihydroxybenzoate

Edukte

CC[C@]12CCCN3CCc4c(n(c5ccccc45)[C@@](O)(C(=O)OC)C1)[C@@H]32
vincamine
O=C(O)c1cc(O)ccc1O
2,5dihydroxybenzoic acid
CC[C@]12CCCN3CCc4c(n(c5ccccc45)[C@@](O)(C(=O)OC)C1)[C@@H]32
vincamine

Reagenzien

Keine

Lösungsmittel

O
water
—
alcohol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

By repeating the Example 5a., starting from 7.08 g (2.10-2 moles) of vincamine and 3.08 g (2.10-2 moles) of 2,5dihydroxybenzoic acid, 10 g are obtained of an amorphous product, insoluble in water and in alcohol, having a vincamine content of 69%.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04122179uspto-grants-1978_10