Reaktion #1199183

Reaktionsgleichung

Ethyl-3-hydroxy-3-methyl-n-nonanoate

potassium hydroxide

→

3-hydroxy-3-methyl-n-nonanoic acid

Ausbeute 83.2%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe ethanol was evaporated in vacuo
2. 2
   workup.ADDITIONthe residue was treated with water (100 ml)
3. 3
   WaschenThe aqueous solution was washed with ether
4. 4
   Temperatur(ice-bath cooling) with dilute hydrochloric acid
5. 5
   SonstigeThe oil that separated
6. 6
   Extraktionwas extracted into ether
7. 7
   WaschenThe ether solution was washed with brine
8. 8
   Trocknenthen was dried over magnesium sulphate
9. 9
   Sonstigeevaporated
10. 10
    Sonstigeto give a light yellow oil
11. 11
    workup.DISTILLATIONThis was vacuum distilled

Vorschrift

Ethyl-3-hydroxy-3-methyl-n-nonanoate (25 g) was refluxed for 3 hours with a 10% solution of potassium hydroxide in dry ethanol (210 ml). The ethanol was evaporated in vacuo and the residue was treated with water (100 ml). The aqueous solution was washed with ether then was acidified (ice-bath cooling) with dilute hydrochloric acid. The oil that separated was extracted into ether. The ether solution was washed with brine then was dried over magnesium sulphate and evaporated to give a light yellow oil. This was vacuum distilled to yield 3-hydroxy-3-methyl-n-nonanoic acid as a clear syrup (18.1g).

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