Reaktion #1197906

Reaktionsgleichung

5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3quinolinecarboxylic acid

triethylamine

acetonitrile

→

5-amino-1-cyclopropyl-6,8-difluoro-1,4 -dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis refluxed for eight hours
2. 2
   SonstigeThe precipitate is removed by filtration
3. 3
   Waschenwashed with acetonitrile
4. 4
   Sonstigedried in vacuo at 45° C.

Vorschrift

A suspension of 1.0 g (3.35 mmole) of 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3quinolinecarboxylic acid, 1.36 g (13.35 mmole) of triethylamine and 60 ml of acetonitrile is refluxed for eight hours and stirred at room temperature for 16 hours. The precipitate is removed by filtration, washed with acetonitrile, and dried in vacuo at 45° C. to give 5-amino-1-cyclopropyl-6,8-difluoro-1,4 -dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, mp 247°-248° C.

Quelle