Reaktion #11976

Reaktionsgleichung

1-(3,4-Dichloro-phenyl)-4,4,4-trifluoro-butane-1,3-dione

5-amino-1H-pyrazole-3-carboxylic acid

→

5-(3,4-dichloro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

Ausbeute 90.9%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 48 hours
2. 2
   EinengenThe reaction concentrated under reduced pressure
3. 3
   Sonstigethe crude product was purified by column chromatography on silica gel

Vorschrift

1-(3,4-Dichloro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (1.00 g, 3.51 mmol) and 5-amino-1H-pyrazole-3-carboxylic acid (0.446 g, 3.51 mmoL) in acetic acid (100 mL) was heated at reflux for 48 hours. The reaction concentrated under reduced pressure and the crude product was purified by column chromatography on silica gel to give 5-(3,4-dichloro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (1.20 g, 90%).

Quelle