Reaktion #11971

Reaktionsgleichung

compound

(2S)-2-(4-(N-Boc-N-2-picolylamino)methylnaphthalene-1-carbonyl)amino-5-((8S)-5,6,7,8-tetrahydroquinolin-8-yl)aminovaleric acid 1-naphthylmethylamide

hydrochloric acid dioxane

→

hydrochloride

title compound

(2S)-2-(4-(N-2-picolylaminomethyl)naphthalene-1-carbonyl)amino-5-((8S)-5,6,7,8-tetrahydroquinolin-8-yl)aminovaleric acid 1-naphthylmethylamide

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter the reaction for 3.5 hours
2. 2
   Einengenthe reaction solution was concentrated
3. 3
   SonstigeThe residue obtained
4. 4
   Sonstigewas purified by silica gel column chromatography (0.5 g, chloroform/methanol/water=7/3/0.5)
5. 5
   workup.ADDITIONtreated with hydrochloric acid

Vorschrift

The compound obtained in Example 90-2 (14.2 mg) was dissolved in methanol (0.3 ml), and 4 mol/l hydrochloric acid/dioxane solution (0.3 ml) was added to the solution. After the reaction for 3.5 hours, the reaction solution was concentrated. The residue obtained was purified by silica gel column chromatography (0.5 g, chloroform/methanol/water=7/3/0.5) and treated with hydrochloric acid to obtain hydrochloride of the title compound (8.1 mg) as a white solid.

Quelle