Reaktion #11965

ord-3ad50d0bff1c4952af0d652c13f73120

Reaktionsgleichung

CC(C)(C)OC(=O)NCC[C@H](NC(=O)c1ccc(CNC(=O)OC(C)(C)C)cc1)C(=O)O
compound
CC(C)(C)OC(=O)NCC[C@H](NC(=O)c1ccc(CNC(=O)OC(C)(C)C)cc1)C(=O)O
(S)-2-(4-(N-Boc-aminomethyl)benzoylamino)-4-(N-Boc-amino)butyric acid
C1COCCO1.Cl
hydrochloric acid dioxane
→
NCC[C@H](NC(=O)c1ccc(CN)cc1)C(=O)O
title compound
Ausbeute 189.4%
NCC[C@H](NC(=O)c1ccc(CN)cc1)C(=O)O
(S)-2-(4-aminomethylbenzoylamino)-4-aminobutyric acid
Ausbeute 189.4%

Edukte

CC(C)(C)OC(=O)NCC[C@H](NC(=O)c1ccc(CNC(=O)OC(C)(C)C)cc1)C(=O)O
compound
CC(C)(C)OC(=O)NCC[C@H](NC(=O)c1ccc(CNC(=O)OC(C)(C)C)cc1)C(=O)O
(S)-2-(4-(N-Boc-aminomethyl)benzoylamino)-4-(N-Boc-amino)butyric acid
C1COCCO1.Cl
hydrochloric acid dioxane

Reagenzien

Keine

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeAfter the reaction
  2. 2
    Sonstigethe solvent was removed by distillation
  3. 3
    Sonstigethe residue was dried

Vorschrift

The compound obtained in Example 60-2 (49.7 mg) was dissolved in methanol (0.5 ml) and 4 mol/l hydrochloric acid/dioxane solution (0.5 ml) was added. The mixture was stirred for 1.5 hours at room temperature. After the reaction, the solvent was removed by distillation and the residue was dried using a vacuum pump to obtain the title compound (52.4 mg) as a white solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07098215B2uspto-grants-2006_08