Reaktion #1196451

Reaktionsgleichung

2,2-dimethyl valeric acid

thionyl chloride

→

product

Ausbeute 88.7%

2,2-dimethyl valeroyl chloride

Ausbeute 88.7%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas cooled in a water bath
2. 2
   Sonstigeexcess thionyl chloride was removed by distillation
3. 3
   workup.DISTILLATIONthe crude acid was then fractionally distilled

Vorschrift

2,2-dimethyl valeric acid (49.0 g, 377 mmol) was added dropwise over 1 hour with stirring to freshly distilled thionyl chloride (102 g, 860 mmol) that was cooled in a water bath. After stirring for an additional 1/2 hour in a warm water bath, excess thionyl chloride was removed by distillation and the crude acid was then fractionally distilled to give 49.7 g of product that assayed >95% by gas chromatography, bp 45°/10.5 mm (lit. bp 45°/10 mm).

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