Reaktion #1195907

Reaktionsgleichung

3-isobutyryl-2-propylindole-6-carboxamide

4-chlorobenzyl bromide

potassium carbonate

→

1-(4-chlorobenzyl)-3-isobutyryl-2-propylindole-6-carboxamide

Ausbeute 66.6%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigepartitioned between ethyl acetate and water
2. 2
   WaschenThe organic layer was washed with water and brine
3. 3
   Trocknendried over magnesium sulfate
4. 4
   SonstigeAfter evaporation of solvent
5. 5
   Sonstigethe residue was crystallized from a mixture of ethyl acetate and hexane
6. 6
   SonstigeThe crude crystals were recrystallized from a mixture of ethyl acetate and hexane

Vorschrift

A mixture of 3-isobutyryl-2-propylindole-6-carboxamide (100 mg), 4-chlorobenzyl bromide (113 mg) and potassium carbonate (152 mg) in dimethylformamide (2 ml) was heated at 60° C. for 2 hours, and partitioned between ethyl acetate and water. The organic layer was washed with water and brine, and dried over magnesium sulfate. After evaporation of solvent, the residue was crystallized from a mixture of ethyl acetate and hexane. The crude crystals were recrystallized from a mixture of ethyl acetate and hexane to give 1-(4-chlorobenzyl)-3-isobutyryl-2-propylindole-6-carboxamide (97 mg) as colorless crystals.

Quelle