Reaktion #1195779

Reaktionsgleichung

8-methoxyquinoline-5-carboxylic acid

Oxalyl chloride

→

title compound

8-Methoxyquinoline-5-carboxylic acid chloride, hydrochloride

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas cooled to 20 C
2. 2
   SonstigeThe solvent was removed in vacuo
3. 3
   Sonstigethe residue azeotroped with a small amount of toluene

Vorschrift

A suspension of 8-methoxyquinoline-5-carboxylic acid (5.0 g) in dichloromethane (50 ml) was cooled to 20 C. Oxalyl chloride (4.29 ml) was added cautiously and then dry dimethylformamide (8 drops) was added dropwise. The mixture was stirred at 0° C. for 1h and then at room temperature for 24h. The solvent was removed in vacuo and the residue azeotroped with a small amount of toluene. The title compound was obtained as a brown solid (5.18 g).

Quelle