Reaktion #1195629

Reaktionsgleichung

sodium methoxide

2-amino-2-cyanoacetamide

acetic acid

glyoxal

→

3-methoxypyrazine-2-carboxamide

Ausbeute 50.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe mixture was stirred at 20° C. for 2 hours
2. 2
   workup.WAITat 50° C. for 2 hours
3. 3
   workup.DISTILLATIONThe solvent was distilled off

Vorschrift

Under argon, 1 g (10.1 mmol) of 2-amino-2-cyanoacetamide was initially charged in 10 g of methanol. 0.25 g (1.4 mmol) of sodium methoxide solution (30%) was added and the mixture was stirred at 20° C. for 2 hours. After neutralization with 0.084 g (1.4 mmol) of acetic acid, 2.27 g (20 mmol) of glyoxal solution (40%) was added. The mixture was stirred at 20° C. for 2 hours and then at 50° C. for 2 hours. The solvent was distilled off. This gave 0.75 g of 3-methyoxypyrazine-2-carboxamide. The yield was 50 percent. Other data concerning the title product was:

Quelle