Reaktion #1195628

Reaktionsgleichung

2-amino-2-cyanoacetamide

sodium methoxide

methylglyoxal

→

title product

3-methoxy-5-methylpyrazine-2-carboxamide

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture was stirred at 0° C. for 2 hours
2. 2
   TemperaturThe solution was then cooled to -20° C
3. 3
   SonstigeThe product precipitated out
4. 4
   FiltrationAfter filtration
5. 5
   Sonstigedrying

Vorschrift

Under argon, 6 g (60.5 mmol) of 2-amino-2-cyanoacetamide was initially charged in 67 g of methanol. 1.67 g (9.3 mmol) of sodium methoxide solution (30%) was added and the mixture was stirred at 20° C. for 2 hours. At 0° C., 11.55 g (64.1 mmol) of methylglyoxal solution (40%) was added and the mixture was stirred at 0° C. for 2 hours. The solution was then cooled to -20° C. The product precipitated out. After filtration and drying, 3.56 g of the title product was obtained. The yield was 39 percent. The melting point of the title product was 170° C. to 172° C. Other data concerning the title product was:

Quelle