Reaktion #11934

ord-5fa1bf7313374de8b97081467abfed33

Reaktionsgleichung

O=C(NCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)OCc1ccccc1
compound
O=C(NCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)OCc1ccccc1
Nα-Fmoc-Nδ-Cbz-L-ornithine
CCNCC
diethylamine
→
N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)O
title compound
Ausbeute 199.4%
N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)O
Nδ-Cbz-L-ornithine
Ausbeute 199.4%

Edukte

O=C(NCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)OCc1ccccc1
compound
O=C(NCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)OCc1ccccc1
Nα-Fmoc-Nδ-Cbz-L-ornithine
CCNCC
diethylamine

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeAfter the reaction
  2. 2
    Sonstigethe solvent was removed by distillation under reduced pressure
  3. 3
    Sonstigethe residue was dried under vacuum

Vorschrift

The compound obtained in Example 8-5 (122.8 mg) was dissolved in DMF (2.6 ml). After the addition of diethylamine (0.26 ml), the mixture was stirred for 2 hours at room temperature. After the reaction, the solvent was removed by distillation under reduced pressure and the residue was dried under vacuum to obtain the title compound (133.5 mg).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07098215B2uspto-grants-2006_08