Reaktion #11929

Reaktionsgleichung

(2-chloro-purin-4-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

4-methylpiperidine

Potassium carbonate

→

solid

Ausbeute 90.0%

[2-(4-Methylpiperidin-1-yl)-purin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine

Ausbeute 90.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas used in the next step without further purification
2. 2
   Temperaturthe reaction mixture heated
3. 3
   Temperaturat reflux overnight
4. 4
   SonstigeThe solvent was evaporated
5. 5
   workup.DISSOLUTIONthe residue dissolved in a mixture EtOH:water (1:3, 4 mL)
6. 6
   FiltrationThe resulting suspension was filtered
7. 7
   Waschenwashed with water (×2)
8. 8
   Waschenrinsed with Et2O (×2)

Vorschrift

To a suspension of 2,4-dichloro-purine (2.0 g, 10.6 mmol) in anhydrous ethanol (10 mL) was added 5-methyl-1H-pyrazol-3-yl amine (2.05 g, 21.2 mmol). The resulting mixture was stirred at room temperature for 48 h. The resulting precipitate was collected by filtration, washed with ethanol, and dried under vacuum to afford 1.524 g (58% yield) of (2-chloro-purin-4-yl)-(5-methyl-1H-pyrazol-3-yl)-amine which was used in the next step without further purification. To a solution of (2-chloro-purin-4-yl)-(5-methyl-1H-pyrazol-3-yl)-amine (200 mg, 0.80 mmol) was added 4-methylpiperidine (4 mL, 8.01 mmol) and the reaction mixture heated at reflux overnight. The solvent was evaporated and the residue dissolved in a mixture EtOH:water (1:3, 4 mL). Potassium carbonate (57 mg, 0.41 mmol) was added and the mixture was stirred at room temperature for 2 hours. The resulting suspension was filtered, washed with water (×2) and rinsed with Et2O (×2) to afford IV-33 as a white solid (225 mg, 90%): mp>300° C.; 1H NMR (DMSO) δ 0.91 (3H, d), 1.10 (2H, m), 1.65 (3H, m), 2.24 (3H, s), 2.84 (2H, m), 4.60 (2H, m), 6.40 (1H, s), 7.87 (1H, m), 9.37–9.59 (1H, m), 12.03–12.39 (2H, m); IR (solid) 1651, 1612, 1574, 1484, 1446, 1327, 1317, 1255, 1203; MS 313.3 (M+H)+.

Quelle