Reaktion #11903
ord-058db254e82c45b7899abb07338a96ad
Reaktionsgleichung
Reagenzien
Keine
Lösungsmittel
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Aufarbeitung
- 1Temperaturwas gently refluxed for about 16–17 h
- 2SonstigeThe solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of 55° C. to 60° C.
Vorschrift
A mixture of trityl candesartan cilexetil (20 g, 23.45 mmol), methanol (200 ml), and water (1 ml) was gently refluxed for about 16–17 h. The reaction progress was monitored by HPLC. The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of 55° C. to 60° C. to obtain viscous oil of candesartan cilexetil as a residue.