Reaktion #11853

Reaktionsgleichung

water

trimethylsilylethyl chloride

2,4-dichloro-1H-pyrrolo[2,3-d]pyrimidine

NaH

MeCN

→

title compound

Ausbeute 104.0%

2,4-Dichloro-7-(2-trimethylsilylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine

Ausbeute 104.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred at room temperature for 3 h
2. 2
   Extraktionextracted with EtOAc
3. 3
   Trocknendried (MgSO4)
4. 4
   Einengenconcentrated in vacuo

Vorschrift

A solution of 2,4-dichloro-1H-pyrrolo[2,3-d]pyrimidine (542 mg, 2.58 mmol) in MeCN (20 mL) was treated with NaH (113 mg, 2.84 mmol), stirred for 1 h, treated with trimethylsilylethyl chloride (502 μL, 2.84 mmol), stirred at room temperature for 3 h, poured into water, extracted with EtOAc, dried (MgSO4) and concentrated in vacuo to give the title compound (913 mg, 104%) which was used crude in the next reaction.

Quelle