Reaktion #1181656

Reaktionsgleichung

cyclohexylamine

Acanthoic acid

(COCl)2

→

acanthoic acid

N-cyclohexylamide

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained by the
2. 2
   SonstigeWhen the reaction stops bubbling
3. 3
   Sonstigethe CH2Cl2 solvent and (COCl)2 can be evaporated under vacuum
4. 4
   workup.DISSOLUTIONthe reaction residue can be redissolved in dry benzene

Vorschrift

Acanthoic acid, including compound obtained by the above described methodology, can be dissolved in dry CH2Cl2 and treated with 10 equivalents of (COCl)2 followed by two drops of DMF. When the reaction stops bubbling, the CH2Cl2 solvent and (COCl)2 can be evaporated under vacuum and the reaction residue can be redissolved in dry benzene and then treated with 5 equivalents of cyclohexylamine to yield N-cyclohexylamide derivative of acanthoic acid.

Quelle