Reaktion #1179627

Reaktionsgleichung

2-(4-ethylbenzyl)-4-bromo-1-chlorobenzene

1,2-dibromoethane

2-(4-ethylbenzyl)-4-bromo-1-chlorobenzene

magnesium

Magnesium

magnesium

→

(4-chloro-3-(4-ethylbenzyl)phenyl)magnesium bromide

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated
2. 2
   Temperaturto reflux
3. 3
   Sonstigeto react for another 1 h
4. 4
   Sonstigewas consumed

Vorschrift

Magnesium powder (34.7 g, 1.446 mol) was charged under argon into a three-necked flask followed by the addition of a portion of a solution of 2-(4-ethylbenzyl)-4-bromo-1-chlorobenzene (122.5 g, 0.398 mol) in anhydrous tetrahydrofuran (0.4 L) and 1,2-dibromoethane (2.89 g, 1.34 mL, 0.015 mol). The mixture was heated to reflux and after reaction initiation (exothermic and consuming magnesium), the rest of the solution of 2-(4-ethylbenzyl)-4-bromo-1-chlorobenzene (245.0 g, 0.796 mol) in anhydrous tetrahydrofuran (0.81 L) was added dropwise. The mixture was then allowed to react for another 1 h under gentle reflux until most of the magnesium was consumed.

Quelle