Reaktion #1178435

ord-acc78d5e7fa9497f9a16dfcb3e5ce3b8

Reaktionsgleichung

O=C(Cl)c1ccc(Cl)s1
5-chlorothiophenecarbonyl chloride
C=O
formaldehyde
NCC(O)C(=O)O
DL-isoserine
O=C([O-])O.[Na+]
sodium hydrogencarbonate
O=C(O)C1CN(C(=O)c2ccc(Cl)s2)CO1
3-(5-chlorothiophene-2-carbonyl)oxazolidine-5-carboxylic acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONDuring the dropwise addition
  2. 2
    workup.ADDITIONWhen the addition
  3. 3
    Extraktionthe mixture is extracted with tert-butyl methyl ether
  4. 4
    Extraktionextracted with tert-butyl methyl ether
  5. 5
    TrocknenThis organic phase is dried over sodium sulfate
  6. 6
    Sonstigeevaporated

Vorschrift

4.1 1.48 ml (19.9 mmol) of 37% aqueous formaldehyde solution are added to a solution of 2.00 g (19.0 mmol) of DL-isoserine in 10 ml of 1N aqueous sodium hydroxide solution. The resultant solution is left at 5° C. for 18 hours. A solution of 3.46 g (19.1 mmol) of 5-chlorothiophenecarbonyl chloride in 10 ml of acetone is added dropwise to this solution at an internal temperature of 0-5° C. During the dropwise addition, the pH is held at a value above 7 by addition of solid sodium hydrogencarbonate. When the addition is complete, the mixture is allowed to warm to room temperature, water is added, and the mixture is extracted with tert-butyl methyl ether. The aqueous phase is acidified using 1N HCl and extracted with tert-butyl methyl ether. This organic phase is dried over sodium sulfate and evaporated, giving 3-(5-chlorothiophene-2-carbonyl)oxazolidine-5-carboxylic acid as a colourless solid; ESI 262. 4.2 479 mg (2.50 mmol) of N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide hydrochloride (DAPECI) are added to a solution of 500 mg (1.91 mmol) of 3-(5-chlorothiophene-2-carbonyl)oxazolidine-5-carboxylic acid and 367 mg (1.91 mmol) of 4-(4-aminophenyl)morpholin-3-one in 5 ml of dimethylformamide (DMF), and the mixture is stirred at room temperature for 18 hours. The reaction mixture is added to saturated sodium hydrogencarbonate solution, and the precipitate formed is filtered off, giving N-[4-(3-oxomorpholin-4-yl)phenyl]-3-(5-chlorothiophene-2-carbonyl)oxazolidine-5-carboxamide (“A5”) as a colourless solid; ESI 436.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08129373B2uspto-grants-2012_03